优德w88手机版本: 首页 >>  学术报告

“生命之述”系列讲座 2019-15 The Human X-linked Autism Protein KIDLIA/NEXMIF in Neurodevelopment and Brain Function

【字体:

讲座人满恒业 教授 波士顿大学

时间10:00

日期2019-07-05

地点:长安校区 格物楼3201会议室

内容简介

X-linked KIAA2022/KIDLIA gene is a new autism gene. We have successfully created a KIAA2022 knockout mouse model which shows typical autism phenotypes as well as impairments in learning and memory. We find that loss of KIAA2022 results in suppression of dendritic growth, a decrease in spine number, synapse formation and synaptic transmission. We are investigating the underlying molecular mechanisms and also exploring means to rescue the molecular dysregulation and behavioral deficits in KIAA2022/KIDLIA knockout mice with the aim to provide therapeutic tools for clinical management of the disorder.

讲座人简介

满恒业教授,美国波士顿大学生物系副主任、博士生导师,生物系终身教授。担任多家杂志包括NeuronNature Neuroscience等的审稿人,美国NIH、英国医学研究委员会等基金的评审。两次获得美国脑与行为基金会的青年科学家奖。主要科研方向包括突触生成及可塑性,谷氨酸受体动态分布及蛋白稳定性的调节机制,神经细胞形态发育,神经发育性和退行性疾病等的细胞分子机制。在多种杂志包括NatureScienceCellNeuronCell ReportsJ NeurosciencePNAS等发表文章70余篇。

版权所有 © 优德w88手机版本